Is the human proteome shrinking?

Is the human proteome (by that, I mean the number of proteins we can express) shrinking the way we've shrank the majestic mastiff into the super majestic pug?Lets look at the evidence:The Scientist this month (thanks Nastratin) reported the results of...

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Search GUI!

I can't hide my love of the friendly and powerful DeNovoGUI from you guys.  What if that easy interface also had a cousin with 4 integrated search engines and the display visualization of the cool PeptideShaker?Then you'd have SearchGUI, yet another...

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The truth about mad scienstists

I tried tracking down the original source for this:  seems like its redditor:  Dualactio...

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Proteogenomic characterization of cancer!

I have been waiting for this stuff to start showing up in bulk!Most biology labs now have tons of "next gen" genomics data on their cells of interest.  Increasingly, these labs are all acquiring proteomics data.  The obvious next step?  Making...

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More on protein quan trumping mRNA quan

More (now old...2013...where have I been...) evidence that protein quan is superior to RNA quan.  In this cool paper in Science from November, researchers looked at the expression levels of RNA and protein in:  humans, chimpanzees and rhesus...

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Heavy analysis of the human proteome drafts

I'm certainly not the only person who has jumped on the new resources provided by the human proteome drafts and checked them out.  In this brand new paper in JPR, a group out of Madrid takes a look at some of their favorite proteins in the human...

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Peptide quan beats RNA quan?!?!?!

This is old news, I guess.  At least everyone at the bar last night knew about this except for me.  In my defense, this field publishes a ton of stuff.  As most y'all know, my background is biology, microbiology to be precise. While I...

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CorConneX -- tools for zero dead volumes

Something cool I learned about this week is the CorConneX.  I have to admit I don't have a concrete understanding of how this works, but it was highly recommended by someone who knows what she's doing! You can read more about it here.  The...

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Cold spring harbor proteomics course!

This week I was lucky enough to get to help out at the Cold Spring Harbor Proteomics Course.  If you aren't familiar, it is probably the most intense bootcamp in proteomics in the world. Want to learn proteomics?  Sign up for next year.  The...

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SIEVE or PD for label free quan

In the context of obtaining peptide IDs, nothing can aid you the way good chromatography does.  More and more, I'm seeing that this is paramount with today's super fast instruments. What about for assigning quantitative data?  How important...

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Sample collection. Level? Super robot!

This week I've been working up in Cape Cod.  Tough life, I know....The proteomics facility at Woods Hole studies biomarkers throughout the ocean and found at different depths.  A complication of the research here is that sample collection requires...

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Captive spray is back for mass specs!

Almost a week with no entries!?!?!  I've been busy...  This one is definitely worth a few minutes of writing.Captive spray is something that has a lot of fans out there.  Recent big business dealings made it go away, however, and now you...

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