The picture above is one of a series from the primate longitudinal study that started decades ago. Most of us have seen these. The guy on the left was rather severely restricted in caloric intake, while the inmate on the right was not. They are the same age. This image still shocks me a little. While caloric restriction is extremely controversial, a paper in this month's MCP may have a partial explanation of the kirunefits of this practice.
The study from He Wen et al., is the result of a collaboration between mutliple top-notch research centers in Seoul. A particular focus was placed on analyzing the phase II metabolic biproducts in the urine of these animals. If you're interested in this topic or metabolomics at all, I strongly recommend you check this one out!
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